I am a certified optician and I have worked wood all my life: I know both worlds well. Here is the honest comparison.
Weight and comfort
Wood is lighter than acetate for the same frame. On your nose, after eight hours, you feel the difference. CREO frames are also designed to your size, so the weight sits where it should.
Durability
Acetate is plastic: stable, predictable, the same for everyone. Well worked wood flexes and absorbs shocks, and with the protective treatment it resists water and sweat. The real difference is another one: acetate dulls and loses color over time, wood ages well.
Uniqueness
Two identical acetate sheets produce thousands of identical frames. Two boards of the same species never produce two identical glasses: grain, knots and shades make every pair one of a kind. Add the personalized engraving and your pair exists in a single copy in the world.
Repairability
A broken acetate frame usually gets replaced. A wooden frame built in a workshop can be repaired in the same workshop that created it, often within a day.
Sustainability
Quality acetate is cotton based but remains an industrial material. Wood is natural and biodegradable, and my workshop runs on minimal waste: one board becomes several frames, and the offcuts become inlays and decorations.
Honest conclusion: acetate is a good industrial material. Wood, worked by hand, is another category of object. Here is how a made-to-measure pair is born.